Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking

Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking

Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was expl...

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Bibliographic Details
Main Authors: Pervaiz Ali Channar, Aamer Saeed, Fernando Albericio, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
jack bean urease inhibition
kinetic mechanism
molecular docking
sulfonamides
drug derivatives
drug discovery
Online Access:https://www.mdpi.com/1420-3049/22/8/1352

Internet

https://www.mdpi.com/1420-3049/22/8/1352

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