Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens

Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens

Abstract CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F CRISPR-Cas in Acinetobacter. CreT is a distinct bactericidal small RNA likely targetin...

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Bibliographic Details
Main Authors: Rui Wang, Xian Shu, Huiwei Zhao, Qiong Xue, Chao Liu, Aici Wu, Feiyue Cheng, Lingyun Wang, Yihan Zhang, Jie Feng, Nannan Wu, Ming Li
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37789-y

Internet

https://doi.org/10.1038/s41467-023-37789-y

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