DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways

DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways

A primary mechanism for activation of innate immunity is recognition of damage or pathogen associated molecular patterns by pattern recognition receptors (PRRs). Nucleic acid is a damage associated molecular pattern molecule that when internalized into a monocyte and recognized by intracellular nucl...

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Bibliographic Details
Main Authors: Amit Porat, Eitan Giat, Czeslawa Kowal, Mingzhu He, Myoungsun Son, Eicke Latz, Ilan Ben-Zvi, Yousef Al-Abed, Betty Diamond
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
type 1 interferon
receptor for advanced glycation end products (RAGE)
Fc receptor gamma 2a
monocytes
systemic lupus erythematosus (SLE)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02824/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02824/full

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