IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

Summary: Inhibitors of apoptosis (IAPs) proteins are critical regulators of innate immune signaling pathways and therefore have potential as drug targets. X-linked IAP (XIAP) and cellular IAP1 and IAP2 (cIAP1 and cIAP2) are E3 ligases that have been shown to be required for signaling downstream of N...

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Bibliographic Details
Main Authors: Che A. Stafford, Kate E. Lawlor, Valentin J. Heim, Aleksandra Bankovacki, Jonathan P. Bernardini, John Silke, Ueli Nachbur
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
innate immunity
NOD2
IAPs
cell signaling
RIPK2
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830041X

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http://www.sciencedirect.com/science/article/pii/S221112471830041X

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