A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

Therapeutic options for Alzheimer&#8217;s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheimer&#8217;s disease-relevant &#94...

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Bibliographic Details
Main Authors: Courtney J. Mycroft-West, Lynsay C. Cooper, Anthony J. Devlin, Patricia Procter, Scott E. Guimond, Marco Guerrini, David G. Fernig, Marcelo A. Lima, Edwin A. Yates, Mark A. Skidmore
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Marine Drugs
Subjects:
Alzheimer’s disease
amyloid-β
BACE1
β-secretase
glycosaminoglycan
heparan sulphate
heparin
<i>Portunus pelagicus</i>
Online Access:https://www.mdpi.com/1660-3397/17/5/293

Internet

https://www.mdpi.com/1660-3397/17/5/293

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