A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheimer’s disease-relevant &#94...

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Bibliographic Details
Main Authors:	Courtney J. Mycroft-West, Lynsay C. Cooper, Anthony J. Devlin, Patricia Procter, Scott E. Guimond, Marco Guerrini, David G. Fernig, Marcelo A. Lima, Edwin A. Yates, Mark A. Skidmore
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Marine Drugs
Subjects:	Alzheimer’s disease amyloid-β BACE1 β-secretase glycosaminoglycan heparan sulphate heparin <i>Portunus pelagicus</i>
Online Access:	https://www.mdpi.com/1660-3397/17/5/293

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