Acquired Nisin Resistance in <italic toggle="yes">Staphylococcus aureus</italic> Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

Acquired Nisin Resistance in <italic toggle="yes">Staphylococcus aureus</italic> Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

ABSTRACT Resistance to the lantibiotic nisin (NIS) arises readily in Staphylococcus aureus as a consequence of mutations in the nsaS gene, which encodes the sensor kinase of the NsaRS two-component regulatory system. Here we present a series of studies to establish how these mutational changes resul...

Full description

Bibliographic Details
Main Authors: Christopher P. Randall, Arya Gupta, Bret Utley-Drew, Siu Yi Lee, Genevieve Morrison-Williams, Alex J. O’Neill
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mSphere
Subjects:
bacteriocin
lantibiotic
resistance studies
staphylococci
Online Access:https://journals.asm.org/doi/10.1128/mSphereDirect.00633-18

Internet

https://journals.asm.org/doi/10.1128/mSphereDirect.00633-18

Similar Items