Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Abstract Background Orotic acid (OA) has been intensively utilized to induce fatty liver in rats. Although the capacity of OA to cause steatosis is species-specific, previous in vitro studies indicate that humans could also be susceptible to OA-induced fatty liver. The aim of the present study was t...

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Bibliographic Details
Main Authors: Johanna Matilainen, Anne-Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P. Sihvo, Petteri Nieminen
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Lipids in Health and Disease
Subjects:
De novo lipogenesis
Hepatocyte
Inflammation
Lipidosis
Non-alcoholic fatty liver disease
Online Access:http://link.springer.com/article/10.1186/s12944-020-01243-5

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http://link.springer.com/article/10.1186/s12944-020-01243-5

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