Effect of Dexamethasone on Abiraterone Pharmacokinetics in Mice: Determined by LC/MS Analysis

Effect of Dexamethasone on Abiraterone Pharmacokinetics in Mice: Determined by LC/MS Analysis

<b>Background:</b> Abiraterone acetate is a cytochrome P450 17A1 (CYP17A1) inhibitor that is indicated for use in both castration-resistant and castration-sensitive prostate cancer patients. To manage the mineralocorticoid effects of CYP17A1 inhibition, a glucocorticoid such as dexametha...

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Bibliographic Details
Main Authors: Subrata Deb, Mohamed Ben-Eltriki, Hans Adomat, Mei Y. Chin, Emma S. Tomlinson Guns
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Medicines
Subjects:
abiraterone
interaction
dexamethasone
cytochrome P450
liquid chromatography–mass spectrometry
Online Access:https://www.mdpi.com/2305-6320/10/3/21

Internet

https://www.mdpi.com/2305-6320/10/3/21

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