Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media pr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02322-8 |
| _version_ | 1818421231975661568 |
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| author | Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido |
| author_facet | Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido |
| author_sort | Holly Rore |
| collection | DOAJ |
| description | Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs). |
| first_indexed | 2024-12-14T13:07:05Z |
| format | Article |
| id | doaj.art-9b0d77b189cb48598785fe29b0ee4f1d |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T13:07:05Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-9b0d77b189cb48598785fe29b0ee4f1d2022-12-21T23:00:18ZengNature PortfolioCommunications Biology2399-36422021-06-014111210.1038/s42003-021-02322-8Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cellsHolly Rore0Nicholas Owen1Raul Eduardo Piña-Aguilar2Kevin Docherty3Ryohei Sekido4Institute of Medical Sciences, Foresterhill, University of AberdeenInstitute of Ophthalmology, University College LondonInstitute of Medical Sciences, Foresterhill, University of AberdeenInstitute of Medical Sciences, Foresterhill, University of AberdeenInstitute of Medical Sciences, Foresterhill, University of AberdeenRore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).https://doi.org/10.1038/s42003-021-02322-8 |
| spellingShingle | Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells Communications Biology |
| title | Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| title_full | Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| title_fullStr | Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| title_full_unstemmed | Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| title_short | Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| title_sort | testicular somatic cell like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells |
| url | https://doi.org/10.1038/s42003-021-02322-8 |
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