Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02205-y |