Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02205-y |
| _version_ | 1818750697455222784 |
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| author | Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid |
| author_facet | Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid |
| author_sort | Nandan Haloi |
| collection | DOAJ |
| description | Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex. |
| first_indexed | 2024-12-18T04:23:48Z |
| format | Article |
| id | doaj.art-9b0ee7be8cd74a3aaff79ae00681eddc |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-18T04:23:48Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-9b0ee7be8cd74a3aaff79ae00681eddc2022-12-21T21:21:09ZengNature PortfolioCommunications Biology2399-36422021-06-014111210.1038/s42003-021-02205-yStructural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-IINandan Haloi0Po-Chao Wen1Qunli Cheng2Meiying Yang3Gayathri Natarajan4Amadou K. S. Camara5Wai-Meng Kwok6Emad Tajkhorshid7Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignDepartment of Anesthesiology, Medical College of WisconsinDepartment of Anesthesiology, Medical College of WisconsinDepartment of Anesthesiology, Medical College of WisconsinDepartment of Anesthesiology, Medical College of WisconsinDepartment of Anesthesiology, Medical College of WisconsinTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignHaloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex.https://doi.org/10.1038/s42003-021-02205-y |
| spellingShingle | Nandan Haloi Po-Chao Wen Qunli Cheng Meiying Yang Gayathri Natarajan Amadou K. S. Camara Wai-Meng Kwok Emad Tajkhorshid Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II Communications Biology |
| title | Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II |
| title_full | Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II |
| title_fullStr | Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II |
| title_full_unstemmed | Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II |
| title_short | Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II |
| title_sort | structural basis of complex formation between mitochondrial anion channel vdac1 and hexokinase ii |
| url | https://doi.org/10.1038/s42003-021-02205-y |
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