A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis

A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis

Abstract Glaucoma is a leading cause of blindness, affecting 70 million people worldwide. Owing to the similarity in anatomy and physiology between human and mouse eyes and the ability to genetically manipulate mice, mouse models are an invaluable resource for studying mechanisms underlying disease...

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Bibliographic Details
Main Authors: Yeming Yang, Xiao Li, Jieping Wang, Junkai Tan, Bernie Fitzmaurice, Patsy M. Nishina, Kuanxiang Sun, Wanli Tian, Wenjing Liu, Xuyang Liu, Bo Chang, Xianjun Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04331-1

Internet

https://doi.org/10.1038/s41419-021-04331-1

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