Development of a Bicistronic Yellow Fever Live Attenuated Vaccine with Reduced Neurovirulence and Viscerotropism

Development of a Bicistronic Yellow Fever Live Attenuated Vaccine with Reduced Neurovirulence and Viscerotropism

ABSTRACT The yellow fever (YF) live attenuated vaccine strain 17D (termed 17D) has been widely used for the prevention and control of YF disease. However, 17D retains significant neurovirulence and viscerotropism in mice, which is probably linked to the increased occurrences of serious adverse event...

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Bibliographic Details
Main Authors: Hong-Jiang Wang, Yan Guo, Meng-Jiao He, Zhong-Yu Liu, Qing Ye, Xing-Yao Huang, Yong-Qiang Deng, Xiao-Feng Li, Cheng-Feng Qin
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
yellow fever
IRES
bicistronic
live attenuated vaccines
neurovirulence
viscerotropism
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02246-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02246-22

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