Analysis of Brain Lipids in the Early-Onset Tay–Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3

Analysis of Brain Lipids in the Early-Onset Tay–Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3

Introduction: Tay–Sachs disease is an autosomal recessively inherited lysosomal storage disease that results from loss-of-function mutations in the HEXA gene coding β-hexosaminidase A. HEXA gene deficiency affects the central nervous system owing to GM2 ganglioside accumulation in lysosomes resultin...

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Bibliographic Details
Main Authors: Melike Can, Tugce Sengül, Secil Akyildiz Demir, Orhan K. İnci, Hande Basırlı, Volkan Seyrantepe
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Tay–Sachs disease
mouse model
lipidomics
brain
gangliosides
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.892248/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.892248/full

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