Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to manipulate their cellular levels and metabolic fate wit...

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Bibliographic Details
Main Authors: Matthijs Kol, Ben Williams, Henry Toombs-Ruane, Henri G Franquelim, Sergei Korneev, Christian Schroeer, Petra Schwille, Dirk Trauner, Joost CM Holthuis, James A Frank
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
atomic force microscopy
sphingomyelin synthase
photopharmacology
ceramide
glucosylceramide
HeLa cells
Online Access:https://elifesciences.org/articles/43230

Internet

https://elifesciences.org/articles/43230

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