Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches

Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches

The inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway is defined as homologous recombination deficiency (HRD). This molecular phenotype represents a positive predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose...

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Bibliographic Details
Main Authors: Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Personalized Medicine
Subjects:
ovarian cancer
homologous recombination deficiency (HRD)
homologous recombination repair (HRR)
next-generation sequencing (NGS)
poly (ADP-ribose) polymerase inhibitor (PARPi)
test
Online Access:https://www.mdpi.com/2075-4426/13/2/284

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https://www.mdpi.com/2075-4426/13/2/284

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