A Missense Variant in CASKIN1’s Proline-Rich Region Segregates with Psychosis in a Three-Generation Family

A Missense Variant in CASKIN1’s Proline-Rich Region Segregates with Psychosis in a Three-Generation Family

The polygenic nature of schizophrenia (SCZ) implicates many variants in disease development. Rare variants of high penetrance have been shown to contribute to the disease prevalence. Whole-exome sequencing of a large three-generation family with SCZ and bipolar disorder identified a single segregati...

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Bibliographic Details
Main Authors: Marah H. Wahbeh, Xi Peng, Sofia Bacharaki, Alexandros Hatzimanolis, Stefanos Dimitrakopoulos, Elizabeth Wohler, Xue Yang, Christian Yovo, Brady J. Maher, Nara Sobreira, Nikos C. Stefanis, Dimitrios Avramopoulos
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Genes
Subjects:
iPSC
stem cells
CRISPR/Cas9
schizophrenia
bipolar disorder
psychiatric disease
Online Access:https://www.mdpi.com/2073-4425/14/1/177

Internet

https://www.mdpi.com/2073-4425/14/1/177

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