SGLT2 Inhibitor–Induced Sympathoinhibition

SGLT2 Inhibitor–Induced Sympathoinhibition

Summary: Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic hypertensive Schlager (BPH/2J) mice reduced blood pressure, improved glucose homeostasis, and reduced renal SGLT2 p...

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Main Authors: Lakshini Y. Herat, PhD, Aaron L. Magno, PhD, Caroline Rudnicka, BSc (Hons), Jana Hricova, BSc, MSc, Revathy Carnagarin, MBBS, MS, MD, PhD, Natalie C. Ward, PhD, Angelique Arcambal, PhD, Marcio G. Kiuchi, MD, MSc, PhD, Geoff A. Head, PhD, Markus P. Schlaich, MD, Vance B. Matthews, PhD
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19303699

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http://www.sciencedirect.com/science/article/pii/S2452302X19303699

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