Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates

Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates

An enzymatic route for phosphorous–carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant β-phosphonomalononitriles via a lipase-catalyzed one-pot Knoevenagel–phospha–Mich...

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Bibliographic Details
Main Authors: Jan Samsonowicz-Górski, Dominik Koszelewski, Paweł Kowalczyk, Paweł Śmigielski, Anastasiia Hrunyk, Karol Kramkowski, Aleksandra Wypych, Mateusz Szymczak, Rafał Lizut, Ryszard Ostaszewski
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
enzyme promiscuity
the phospha-Michael addition
antimicrobial activity
lipase
<i>Candida cylindracea</i>
bio catalysis
Online Access:https://www.mdpi.com/1422-0067/23/15/8819

Internet

https://www.mdpi.com/1422-0067/23/15/8819

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