Structure–Activity Relationship of <i>N</i>-Phenylthieno[2,3-<i>b</i>]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

Structure–Activity Relationship of <i>N</i>-Phenylthieno[2,3-<i>b</i>]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

We report synthesis, characterization, biological evaluation, and molecular-docking studies of 18 thieno[2,3-<i>b</i>]pyridines with a phenylacetamide moiety at position 2, which is disubstituted with F, Cl, Br, or I at position 4, and with electron-withdrawing and electron-donating grou...

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Bibliographic Details
Main Authors: César Sebastian Huerta-García, David J. Pérez, Carlos A. Velázquez-Martínez, Seyed Amirhossein Tabatabaei Dakhili, Antonio Romo-Mancillas, Rafael Castillo, Alicia Hernández-Campos
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
thieno[2,3-<i>b</i>]pyridines
FOXM1
transcription factor
cancer
Online Access:https://www.mdpi.com/1424-8247/15/3/283

Internet

https://www.mdpi.com/1424-8247/15/3/283

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