The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation

The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation

The pleiotropic chemokine (C-X-C motif) ligand 12 (CXCL12) has emerged as a crucial player in several diseases. The role of CXCL12 in diabetes promotion and progression remains elusive due to its multiple functions and the overwhelming complexity of diabetes. Diabetes is a metabolic disorder resulti...

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Bibliographic Details
Main Authors: Melita eVidakovic, Nevena eGrdovic, Svetlana eDinic, Mirjana eMihailovic, Aleksandra eUskokovic, Jelena eArambasic Jovanovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Diabetes Mellitus
CXCR4
diabetic complications
CXCL12
CXCR7
pancreatic beta-cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00403/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00403/full

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