The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation
The pleiotropic chemokine (C-X-C motif) ligand 12 (CXCL12) has emerged as a crucial player in several diseases. The role of CXCL12 in diabetes promotion and progression remains elusive due to its multiple functions and the overwhelming complexity of diabetes. Diabetes is a metabolic disorder resulti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00403/full |
| _version_ | 1818522525945036800 |
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| author | Melita eVidakovic Nevena eGrdovic Svetlana eDinic Mirjana eMihailovic Aleksandra eUskokovic Jelena eArambasic Jovanovic |
| author_facet | Melita eVidakovic Nevena eGrdovic Svetlana eDinic Mirjana eMihailovic Aleksandra eUskokovic Jelena eArambasic Jovanovic |
| author_sort | Melita eVidakovic |
| collection | DOAJ |
| description | The pleiotropic chemokine (C-X-C motif) ligand 12 (CXCL12) has emerged as a crucial player in several diseases. The role of CXCL12 in diabetes promotion and progression remains elusive due to its multiple functions and the overwhelming complexity of diabetes. Diabetes is a metabolic disorder resulting from a failure in glucose regulation due to beta-cell loss and/or dysfunction. In view of its ability to stimulate the regeneration, proliferation and survival of beta-cells, as well as its capacity to sustain local immune-isolation, CXCL12 has been considered in approaches aimed at attenuating type 1 diabetes. However, a note of caution emerges from examinations of the involvement of CXCL12 in the development of diabetes and its complications, as research data indicate that CXCL12 displays effects that range from protective to detrimental. Therefore, as a beneficial effect of CXCL12 in one process could have deleterious consequences in another, a more complete understanding of CXCL12 effects, in particular its functioning in the cellular microenvironment is essential before CXCL12 can be considered in therapies for diabetes treatment. |
| first_indexed | 2024-12-11T05:34:23Z |
| format | Article |
| id | doaj.art-9b227f4dd8b84269962071cc8767cbc3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T05:34:23Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9b227f4dd8b84269962071cc8767cbc32022-12-22T01:19:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-08-01610.3389/fimmu.2015.00403150764The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuationMelita eVidakovic0Nevena eGrdovic1Svetlana eDinic2Mirjana eMihailovic3Aleksandra eUskokovic4Jelena eArambasic Jovanovic5Institute for Biological Research, University of BelgradeInstitute for Biological Research, University of BelgradeInstitute for Biological Research, University of BelgradeInstitute for Biological Research, University of BelgradeInstitute for Biological Research, University of BelgradeInstitute for Biological Research, University of BelgradeThe pleiotropic chemokine (C-X-C motif) ligand 12 (CXCL12) has emerged as a crucial player in several diseases. The role of CXCL12 in diabetes promotion and progression remains elusive due to its multiple functions and the overwhelming complexity of diabetes. Diabetes is a metabolic disorder resulting from a failure in glucose regulation due to beta-cell loss and/or dysfunction. In view of its ability to stimulate the regeneration, proliferation and survival of beta-cells, as well as its capacity to sustain local immune-isolation, CXCL12 has been considered in approaches aimed at attenuating type 1 diabetes. However, a note of caution emerges from examinations of the involvement of CXCL12 in the development of diabetes and its complications, as research data indicate that CXCL12 displays effects that range from protective to detrimental. Therefore, as a beneficial effect of CXCL12 in one process could have deleterious consequences in another, a more complete understanding of CXCL12 effects, in particular its functioning in the cellular microenvironment is essential before CXCL12 can be considered in therapies for diabetes treatment.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00403/fullDiabetes MellitusCXCR4diabetic complicationsCXCL12CXCR7pancreatic beta-cells |
| spellingShingle | Melita eVidakovic Nevena eGrdovic Svetlana eDinic Mirjana eMihailovic Aleksandra eUskokovic Jelena eArambasic Jovanovic The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation Frontiers in Immunology Diabetes Mellitus CXCR4 diabetic complications CXCL12 CXCR7 pancreatic beta-cells |
| title | The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation |
| title_full | The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation |
| title_fullStr | The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation |
| title_full_unstemmed | The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation |
| title_short | The importance of the CXCL12/CXCR4 axis in therapeutic approaches to Diabetes mellitus attenuation |
| title_sort | importance of the cxcl12 cxcr4 axis in therapeutic approaches to diabetes mellitus attenuation |
| topic | Diabetes Mellitus CXCR4 diabetic complications CXCL12 CXCR7 pancreatic beta-cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00403/full |
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