Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts

Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts

IntroductionThe rVSVDG-ZEBOV-GP (Ervebo®) vaccine is both immunogenic and protective against Ebola. However, the vaccine can cause a broad range of transient adverse reactions, from headache to arthritis. Identifying baseline reactogenicity signatures can advance personalized vaccinology and increas...

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Main Authors: Patrícia Conceição Gonzalez Dias Carvalho, Thiago Dominguez Crespo Hirata, Leandro Yukio Mano Alves, Isabelle Franco Moscardini, Ana Paula Barbosa do Nascimento, André G. Costa-Martins, Sara Sorgi, Ali M. Harandi, Daniela M. Ferreira, Eleonora Vianello, Mariëlle C. Haks, Tom H. M. Ottenhoff, Francesco Santoro, Paola Martinez-Murillo, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Helder I. Nakaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Ebola
rVSVDG-ZEBOV-GP vaccine
baseline gene signatures
adverse events
vaccine safety
personalized vaccinology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1259197/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1259197/full

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