USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN

USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN

Background: Polycystic ovarian syndrome (PCOS) is an endocrine-related disease related to abnormal folliculogenesis and is a leading cause of infertility worldwide. Inhibition of granulosa cells (GCs) proliferation and increased GCs apoptosis have been identified as the major factors in aberrant fol...

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Bibliographic Details
Main Authors: Yue Gao, Jiao Chen, Rui Ji, Jinli Ding, Yan Zhang, Jing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
USP25
PTEN
PCOS
PI3K/AKT
deubiquitinating
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.779718/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.779718/full

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