Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism

Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism

We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3<i>H</i>)-one (Q1) from the natural citral. The concentration, which led to 50% activity loss of Q1, was 1...

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Bibliographic Details
Main Authors: Yaru Huang, Jiefang Yang, Yunyang Chi, Chun Gong, Haikuan Yang, Fanxin Zeng, Fang Gao, Xiaoju Hua, Zongde Wang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
tyrosinase
inhibitor
citral
derivatives
fluorescence quenching
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/17/5558

Internet

https://www.mdpi.com/1420-3049/27/17/5558

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