Enrichment post-library preparation enhances the sensitivity of high-throughput sequencing-based detection and characterization of viruses from complex samples

Enrichment post-library preparation enhances the sensitivity of high-throughput sequencing-based detection and characterization of viruses from complex samples

Abstract Background Sequencing-based detection and characterization of viruses in complex samples can suffer from lack of sensitivity due to a variety of factors including, but not limited to, low titer, small genome size, and contribution of host or environmental nucleic acids. Hybridization-based...

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Bibliographic Details
Main Authors: Adrian C. Paskey, Kenneth G. Frey, Gary Schroth, Stephen Gross, Theron Hamilton, Kimberly A. Bishop-Lilly
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Genomics
Subjects:
Genome enrichment
Virus detection
High-throughput sequencing
Virome profiling
Virome capture sequencing
Viral enrichment
Online Access:http://link.springer.com/article/10.1186/s12864-019-5543-2

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http://link.springer.com/article/10.1186/s12864-019-5543-2

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