Towards the controlled enzymatic synthesis of LNA containing oligonucleotides

Towards the controlled enzymatic synthesis of LNA containing oligonucleotides

Enzymatic, de novo XNA synthesis represents an alternative method for the production of long oligonucleotides containing chemical modifications at distinct locations. While such an approach is currently developed for DNA, controlled enzymatic synthesis of XNA remains at a relative state of infancy....

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Bibliographic Details
Main Authors: Nazarii Sabat, Dace Katkevica, Karlis Pajuste, Marie Flamme, Andreas Stämpfli, Martins Katkevics, Steven Hanlon, Serena Bisagni, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Chemistry
Subjects:
locked nucleic acids (LNA)
XNA
modified nucleotides
polymerases
controlled enzymatic synthesis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1161462/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1161462/full

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