Implementing Pre-Therapeutic <i>UGT1A1</i> Genotyping in Clinical Practice: A Real-Life Study

Implementing Pre-Therapeutic <i>UGT1A1</i> Genotyping in Clinical Practice: A Real-Life Study

Current guidelines recommend pre-therapeutic <i>UGT1A1</i> genotyping to guide irinotecan dosing, but the usefulness of this approach remains to be clarified. In 247 patients with advanced gastrointestinal cancers undergoing irinotecan-based chemotherapy, we prospectively performed <i...

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Bibliographic Details
Main Authors: Nicola Personeni, Laura Giordano, Angelica Michelini, Antonio D’Alessio, Antonella Cammarota, Silvia Bozzarelli, Tiziana Pressiani, Maria Giuseppina Prete, Maria Teresa Sandri, Sabine Stioui, Luca Germagnoli, Armando Santoro, Lorenza Rimassa, Rossana Mineri
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Journal of Personalized Medicine
Subjects:
irinotecan
UGT1A1
pharmacogenomics
metastatic cancer
Online Access:https://www.mdpi.com/2075-4426/12/2/204

Internet

https://www.mdpi.com/2075-4426/12/2/204

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