Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that nee...

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Bibliographic Details
Main Authors: Rajula Elango, Ziwei Sheng, Jessica Jackson, Jenna DeCata, Younis Ibrahim, Nhung T. Pham, Diana H. Liang, Cynthia J. Sakofsky, Alessandro Vindigni, Kirill S. Lobachev, Grzegorz Ira, Anna Malkova
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01987-2

Internet

https://doi.org/10.1038/s41467-017-01987-2

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