Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that nee...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01987-2 |
| _version_ | 1818433693724704768 |
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| author | Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova |
| author_facet | Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova |
| author_sort | Rajula Elango |
| collection | DOAJ |
| description | Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1. |
| first_indexed | 2024-12-14T16:25:09Z |
| format | Article |
| id | doaj.art-9b329335ec744672ad3e5e67091d04d5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:25:09Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9b329335ec744672ad3e5e67091d04d52022-12-21T22:54:42ZengNature PortfolioNature Communications2041-17232017-11-018111310.1038/s41467-017-01987-2Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2Rajula Elango0Ziwei Sheng1Jessica Jackson2Jenna DeCata3Younis Ibrahim4Nhung T. Pham5Diana H. Liang6Cynthia J. Sakofsky7Alessandro Vindigni8Kirill S. Lobachev9Grzegorz Ira10Anna Malkova11Department of Biology, University of IowaSchool of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyEdward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineDepartment of Biology, University of IowaDepartment of Biology, University of IowaDepartment of Molecular & Human Genetics, Baylor College of MedicineDepartment of Molecular & Human Genetics, Baylor College of MedicineDepartment of Biology, University of IowaEdward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineSchool of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyDepartment of Molecular & Human Genetics, Baylor College of MedicineDepartment of Biology, University of IowaBreak-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1.https://doi.org/10.1038/s41467-017-01987-2 |
| spellingShingle | Rajula Elango Ziwei Sheng Jessica Jackson Jenna DeCata Younis Ibrahim Nhung T. Pham Diana H. Liang Cynthia J. Sakofsky Alessandro Vindigni Kirill S. Lobachev Grzegorz Ira Anna Malkova Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 Nature Communications |
| title | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 |
| title_full | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 |
| title_fullStr | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 |
| title_full_unstemmed | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 |
| title_short | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 |
| title_sort | break induced replication promotes formation of lethal joint molecules dissolved by srs2 |
| url | https://doi.org/10.1038/s41467-017-01987-2 |
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