K‐Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines

K‐Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines

Advanced biliary tract cancer (BTC) has a poor prognosis and limited treatment options. The PI3K/Akt/mTOR signalling pathway is hyperactivated in a subset of BTCs, and clinical activity of the mTOR inhibitor everolimus has been observed in some patients with BTC. The goal of this study was to identi...

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Bibliographic Details
Main Authors: Yvonne Yeung, David K. Lau, Fiona Chionh, Hoanh Tran, Janson W. T. Tse, Andrew J. Weickhardt, Mehrdad Nikfarjam, Andrew M. Scott, Niall C. Tebbutt, John M. Mariadason
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:Molecular Oncology
Subjects:
AKT
biliary tract cancer
everolimus
K‐Ras
mTOR
Online Access:https://doi.org/10.1002/1878-0261.12078

Internet

https://doi.org/10.1002/1878-0261.12078

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