De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Here, the authors identify and validate the emergence of a SARS-CoV-2 resistance mutation to Remdesivir, associated with virological recrudesce in an immunocompromised patient with persistent COVID-19.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29104-y |
| _version_ | 1811273503535529984 |
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| author | Shiv Gandhi Jonathan Klein Alexander J. Robertson Mario A. Peña-Hernández Michelle J. Lin Pavitra Roychoudhury Peiwen Lu John Fournier David Ferguson Shah A. K. Mohamed Bakhash M. Catherine Muenker Ariktha Srivathsan Elsio A. Wunder Nicholas Kerantzas Wenshuai Wang Brett Lindenbach Anna Pyle Craig B. Wilen Onyema Ogbuagu Alexander L. Greninger Akiko Iwasaki Wade L. Schulz Albert I. Ko |
| author_facet | Shiv Gandhi Jonathan Klein Alexander J. Robertson Mario A. Peña-Hernández Michelle J. Lin Pavitra Roychoudhury Peiwen Lu John Fournier David Ferguson Shah A. K. Mohamed Bakhash M. Catherine Muenker Ariktha Srivathsan Elsio A. Wunder Nicholas Kerantzas Wenshuai Wang Brett Lindenbach Anna Pyle Craig B. Wilen Onyema Ogbuagu Alexander L. Greninger Akiko Iwasaki Wade L. Schulz Albert I. Ko |
| author_sort | Shiv Gandhi |
| collection | DOAJ |
| description | Here, the authors identify and validate the emergence of a SARS-CoV-2 resistance mutation to Remdesivir, associated with virological recrudesce in an immunocompromised patient with persistent COVID-19. |
| first_indexed | 2024-04-12T23:00:22Z |
| format | Article |
| id | doaj.art-9b3a77f831774145b06a422bbfb8f3de |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T23:00:22Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9b3a77f831774145b06a422bbfb8f3de2022-12-22T03:13:04ZengNature PortfolioNature Communications2041-17232022-03-011311810.1038/s41467-022-29104-yDe novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case reportShiv Gandhi0Jonathan Klein1Alexander J. Robertson2Mario A. Peña-Hernández3Michelle J. Lin4Pavitra Roychoudhury5Peiwen Lu6John Fournier7David Ferguson8Shah A. K. Mohamed Bakhash9M. Catherine Muenker10Ariktha Srivathsan11Elsio A. Wunder12Nicholas Kerantzas13Wenshuai Wang14Brett Lindenbach15Anna Pyle16Craig B. Wilen17Onyema Ogbuagu18Alexander L. Greninger19Akiko Iwasaki20Wade L. Schulz21Albert I. Ko22Section of Infectious Diseases, Department of Medicine, Yale University School of MedicineDepartment of Immunobiology, Yale University School of MedicineDepartment of Epidemiology of Microbial Diseases, Yale School of Public HealthDepartment of Immunobiology, Yale University School of MedicineDepartment of Laboratory Medicine, University of Washington School of MedicineDepartment of Laboratory Medicine, University of Washington School of MedicineDepartment of Immunobiology, Yale University School of MedicineSection of Infectious Diseases, Department of Medicine, Yale University School of MedicineCenter for Outcomes Research and Evaluation, Yale New Haven HospitalDepartment of Laboratory Medicine, University of Washington School of MedicineDepartment of Epidemiology of Microbial Diseases, Yale School of Public HealthDepartment of Epidemiology of Microbial Diseases, Yale School of Public HealthDepartment of Epidemiology of Microbial Diseases, Yale School of Public HealthDepartment of Laboratory Medicine, Yale School of MedicineDepartment of Molecular, Cellular and Developmental Biology, Yale UniversityDepartment of Microbial Pathogenesis, Yale School of MedicineDepartment of Molecular, Cellular and Developmental Biology, Yale UniversityDepartment of Immunobiology, Yale University School of MedicineSection of Infectious Diseases, Department of Medicine, Yale University School of MedicineDepartment of Laboratory Medicine, University of Washington School of MedicineDepartment of Immunobiology, Yale University School of MedicineCenter for Outcomes Research and Evaluation, Yale New Haven HospitalSection of Infectious Diseases, Department of Medicine, Yale University School of MedicineHere, the authors identify and validate the emergence of a SARS-CoV-2 resistance mutation to Remdesivir, associated with virological recrudesce in an immunocompromised patient with persistent COVID-19.https://doi.org/10.1038/s41467-022-29104-y |
| spellingShingle | Shiv Gandhi Jonathan Klein Alexander J. Robertson Mario A. Peña-Hernández Michelle J. Lin Pavitra Roychoudhury Peiwen Lu John Fournier David Ferguson Shah A. K. Mohamed Bakhash M. Catherine Muenker Ariktha Srivathsan Elsio A. Wunder Nicholas Kerantzas Wenshuai Wang Brett Lindenbach Anna Pyle Craig B. Wilen Onyema Ogbuagu Alexander L. Greninger Akiko Iwasaki Wade L. Schulz Albert I. Ko De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report Nature Communications |
| title | De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report |
| title_full | De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report |
| title_fullStr | De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report |
| title_full_unstemmed | De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report |
| title_short | De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report |
| title_sort | de novo emergence of a remdesivir resistance mutation during treatment of persistent sars cov 2 infection in an immunocompromised patient a case report |
| url | https://doi.org/10.1038/s41467-022-29104-y |
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