DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice

DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice

Background We investigated the antidiabetic effects of DA-1241, a novel G protein-coupled receptor (GPR) 119 agonist, in vitro and in vivo. Methods DA-1241 was administrated to high-fat diet (HFD)-fed C57BL/6J mice for 12 weeks after hyperglycaemia developed. Oral/intraperitoneal glucose tolerance t...

Full description

Bibliographic Details
Main Authors: Youjin Kim, Si Woo Lee, Hyejin Wang, Ryeong-Hyeon Kim, Hyun Ki Park, Hangkyu Lee, Eun Seok Kang
Format: Article
Language:English
Published: Korean Diabetes Association 2022-03-01
Series:Diabetes & Metabolism Journal
Subjects:
autophagy
glucagon-like peptide 1
gluconeogenesis
g protein-coupled receptor
insulin secretion
Online Access:http://e-dmj.org/upload/pdf/dmj-2021-0056.pdf

Internet

http://e-dmj.org/upload/pdf/dmj-2021-0056.pdf

Similar Items