Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this mechanism operates, nor whether it can selecti...

Full description

Bibliographic Details
Main Authors: Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia CS Wunderlich, Pedro Vallejo-Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Clemens F Kaminski, William A Harris, John G Flanagan, Christine E Holt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
local protein synthesis
axon
guidance receptor
retinal ganglion cell
mRNA
RNA-binding protein
Online Access:https://elifesciences.org/articles/48718

Internet

https://elifesciences.org/articles/48718

Similar Items