ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias

ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias

Abstract Deletion of ABL1 was detected in a cohort of hematologic malignancies carrying AML1-ETO and NUP98 fusion proteins. Abl1−/− murine hematopoietic cells transduced with AML1-ETO and NUP98-PMX1 gained proliferation advantage when compared to Abl1 + /+ counterparts. Conversely, overexpression an...

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Bibliographic Details
Main Authors: Konstantin Golovine, Gleb Abalakov, Zhaorui Lian, Srinivas Chatla, Adam Karami, Kumaraswamy Naidu Chitrala, Jozef Madzo, Margaret Nieborowska-Skorska, Jian Huang, Tomasz Skorski
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-023-00810-0

Internet

https://doi.org/10.1038/s41408-023-00810-0

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