Plasma membrane SK2 channel activity regulates migration and chemosensitivity of high‐grade serous ovarian cancer cells

Plasma membrane SK2 channel activity regulates migration and chemosensitivity of high‐grade serous ovarian cancer cells

No data are currently available on the functional role of small conductance Ca2+‐activated K+ channels (SKCa) in ovarian cancer. Here, we characterized the role of SK2 (KCa2.2) in ovarian cancer cell migration and chemosensitivity. Using the selective non‐cell‐permeant SK2 inhibitor Lei‐Dab7, we ide...

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Bibliographic Details
Main Authors: Olivier Romito, Aude Lemettre, Aurélie Chantôme, Ophélie Champion, Noémie Couty, Lobna Ouldamer, Nadine Hempel, Mohamed Trebak, Caroline Goupille, Marie Potier‐Cartereau
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Molecular Oncology
Subjects:
cell migration
chemosensitivity
high‐grade serous ovarian cancer
LPA
SK2 channel
Taxol®
Online Access:https://doi.org/10.1002/1878-0261.13631

Internet

https://doi.org/10.1002/1878-0261.13631

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