Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12377-1 |