Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies

Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies

Direct FXa inhibitors are an important class of bioactive molecules (rivaroxaban, apixaban, edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular pathologies. The interaction of active compounds with human serum albumin (HSA), the most abundant protein in blood plasma, i...

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Bibliographic Details
Main Authors: Nory Mariño-Ocampo, Diego F. Rodríguez, Daniel Guerra Díaz, Daniel Zúñiga-Núñez, Yorley Duarte, Denis Fuentealba, Flavia C. Zacconi
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
FXa inhibitors
human serum albumin
fluorescence
isothermal titration calorimetry
molecular modeling
direct oral FXa inhibitors
Online Access:https://www.mdpi.com/1422-0067/24/5/4900

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https://www.mdpi.com/1422-0067/24/5/4900

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