Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

Summary: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe vaccination strategies to broaden SARS-CoV-2 and sarbecovirus immunity by combining spike proteins based on different viruses or viral...

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Bibliographic Details
Main Authors: Mitch Brinkkemper, Tim S. Veth, Philip J.M. Brouwer, Hannah Turner, Meliawati Poniman, Judith A. Burger, Joey H. Bouhuijs, Wouter Olijhoek, Ilja Bontjer, Jonne L. Snitselaar, Tom G. Caniels, Cynthia A. van der Linden, Rashmi Ravichandran, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Andrew B. Ward, Neil P. King, Albert J.R. Heck, Rogier W. Sanders
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Immunology
Immune response
Microbiology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019216

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222019216

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