Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms

Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms

High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 >20%. At present, no specific therapy for H-NENs...

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Bibliographic Details
Main Authors: Giovanni Centonze, Vincenzo Lagano, Giovanna Sabella, Alessandro Mangogna, Giovanna Garzone, Martina Filugelli, Beatrice Belmonte, Laura Cattaneo, Valentina Crisafulli, Alessio Pellegrinelli, Michele Simbolo, Aldo Scarpa, Paola Spaggiari, Tatiana Brambilla, Sara Pusceddu, Natalie Prinzi, Andrea Anichini, Claudio Tripodo, Massimo Milione
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Clinical Medicine
Subjects:
gastroenteropancreatic neuroendocrine neoplasms
tumor microenvironment
myeloid markers
Online Access:https://www.mdpi.com/2077-0383/10/8/1741

Internet

https://www.mdpi.com/2077-0383/10/8/1741

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