Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

The hepatitis B virus (HBV) infects many people worldwide. As HBV infection frequently leads to liver fibrosis and carcinogenesis, developing anti-HBV therapeutic drugs is urgent. Therapeutic drugs for preventing covalently closed circular DNA (cccDNA) production, which can eliminate HBV infection,...

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Bibliographic Details
Main Authors: Hikari Okada, Takeharu Sakamoto, Kouki Nio, Yingyi Li, Kazuyuki Kuroki, Saiho Sugimoto, Tetsuro Shimakami, Nobuhide Doi, Masao Honda, Motoharu Seiki, Shuichi Kaneko, Taro Yamashita
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cccDNA
DOCK11
gapmer
HBV
hetero gapmer
LNP-siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124001050

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http://www.sciencedirect.com/science/article/pii/S2329050124001050

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