Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach

The inter-individual variability of CYP450s enzyme activity may be reduced by comparing the effects of bariatric surgery on CYP-mediated drug elimination in comparable patients before and after surgery. The current research will use a low-dose phenotyping cocktail to simultaneously evaluate the acti...

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Bibliographic Details
Main Authors: Hengameh Ghasim, Mohammadreza Rouini, Saeed Safari, Farnoosh Larti, Mohammadreza Khoshayand, Kheirollah Gholami, Navid Neyshaburinezhad, Yvonne Gloor, Youssef Daali, Yalda H. Ardakani
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Personalized Medicine
Subjects:
phenoconversion
bariatric surgery
CYP450 phenotype and genotype
cocktail
personalized medicine
Online Access:https://www.mdpi.com/2075-4426/13/7/1042

Internet

https://www.mdpi.com/2075-4426/13/7/1042

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