Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer

Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer

The use of immune checkpoint inhibitors to treat cancer resulted in unprecedented and durable clinical benefits. However, the response rate among patients remains rather modest. Previous work from our laboratory demonstrated the efficacy of using attenuated bacteria as immunomodulatory anti-cancer a...

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Bibliographic Details
Main Authors: Besan H. Al-Saafeen, Ashraf Al-Sbiei, Ghada Bashir, Yassir A. Mohamed, Razan J. Masad, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
immune checkpoints inhibitors
PD-L1 blockade
Salmonella typhimurium
immunotherapy
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017780/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017780/full

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