Determining drug dose in the era of targeted therapies: playing it (un)safe?

Abstract Targeted therapies against phosphatidylinositol 3-kinase (PI3K), Bruton’s tyrosine kinase (BTK), and B-cell lymphoma-2 (BCL-2) are approved for chronic lymphocytic leukemia (CLL). Since approval of the first-in-class drugs, next-generation agents have become available and are continuously u...

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Bibliographic Details
Main Authors: Sigrid S. Skånland, Geir E. Tjønnfjord
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-022-00720-7