Pembrolizumab Activity in Recurrent High-Grade Gliomas with Partial or Complete Loss of Mismatch Repair Protein Expression: A Monocentric, Observational and Prospective Pilot Study

Pembrolizumab Activity in Recurrent High-Grade Gliomas with Partial or Complete Loss of Mismatch Repair Protein Expression: A Monocentric, Observational and Prospective Pilot Study

Introduction: Pembrolizumab demonstrated promising results in hypermutated tumors of diverse origin. Immunohistochemical loss of mismatch repair (MMR) proteins has been suggested as a surrogate of hypermutation in high-grade gliomas (HGG). We evaluated the efficacy and safety of pembrolizumab in rel...

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Main Authors: Giuseppe Lombardi, Valeria Barresi, Stefano Indraccolo, Michele Simbolo, Matteo Fassan, Susanna Mandruzzato, Matteo Simonelli, Mario Caccese, Marco Pizzi, Arianna Fassina, Marta Padovan, Elena Masetto, Marina Paola Gardiman, Maria Giuseppina Bonavina, Maria Caffo, Pasquale Persico, Franco Chioffi, Luca Denaro, Angelo Paolo Dei Tos, Aldo Scarpa, Vittorina Zagonel
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
pembrolizumab
mismatch repair
high grade glioma
glioblastoma
TMB
Online Access:https://www.mdpi.com/2072-6694/12/8/2283

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https://www.mdpi.com/2072-6694/12/8/2283

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