The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but subsequently inactivated in response to membrane...

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Bibliographic Details
Main Authors: Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:FEBS Open Bio
Subjects:
channel
inactivation
PKD2L1
transient receptor potential
TRPP3
Online Access:https://doi.org/10.1002/2211-5463.12273

Internet

https://doi.org/10.1002/2211-5463.12273

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