Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients

Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients

Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and plausible IBD-causing genes from the exomes of 4453...

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Detalhes bibliográficos
Principais autores: Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2023-04-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-37849-3

Internet

https://doi.org/10.1038/s41467-023-37849-3

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