Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

Starting from the structure of antimycobacterial screening hit OTB-021 which was devoid of activity against ESKAPE pathogens, we designed, synthesized and tested two mutually isomeric series of novel simplified analogs, 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines, bearing various amino side cha...

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Bibliographic Details
Main Authors: Sergey Chuprun, Dmitry Dar’in, Elizaveta Rogacheva, Liudmila Kraeva, Oleg Levin, Olga Manicheva, Marine Dogonadze, Tatiana Vinogradova, Olga Bakulina, Mikhail Krasavin
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antibiotics
Subjects:
bioreducible prodrugs
nitroazoles
3-nitro-1,2,4-triazole
nucleophilic aromatic substitution
antimycobacterial activity
ESKAPE pathogens
Online Access:https://www.mdpi.com/2079-6382/9/10/666

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https://www.mdpi.com/2079-6382/9/10/666

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