T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoBRR has been attributed in part to pathogen-d...

Full description

Bibliographic Details
Main Authors: Jaclyn R. Espinosa, Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, Mingqing Song, Linda L. Stempora, Jun Wang, Neal N. Iwakoshi, Allan D. Kirk
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
costimulation blockade
T cell memory
viral infections
heterotopic heart transplantation
alloimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01371/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01371/full

Similar Items